RAC Guidance - Lentivirus Containment

Biosafety Considerations for Research with

Lentiviral Vectors

Credit: ICTVdB¹




	Credit: NIAID

At the March 15, 2006 RAC meeting, the RAC discussed the conduct of risk assessments and determination of containment for lentiviral vector research. The NIH Guidelines for Research Involving Recombinant DNA Molecules do not directly address the use of lentiviral vectors. To provide additional guidance to Institutional Biosafety Committees and investigators, OBA organized a working group of RAC and ad hoc reviewers with virology and biosafety expertise to develop some general criteria to be considered when conducting risk assessments for research involving lentiviral vectors.

Guidance on Biosafety Considerations for Research with Lentiviral Vectors

Webcast and Slides

Minutes of the March 2006 RAC Meeting

Minutes of the June 2006 RAC Meeting

Minutes of the September 2006 RAC Meeting

Reviews and Recommendations:

Nikunj V. Somia, Ph.D.
RAC Member
Molecular Genetics Institute
University of Minnesota, Twin Cities

Stephen Dewhurst, Ph.D.
RAC Member
Department of Microbiology and Immunology
University of Rochester Medical Center

Naomi Rosenberg, Ph.D.
RAC Member
Department of Pathology
Tufts University, School of Medicine

LouAnn C. Burnett, M.S., CBSP
Ad-Hoc Expert
Environmental Health and Safety Department
Vanderbilt University

¹NIH OBA gratefully acknowledges James Whitehead, Cornelia Buchen-Osmond and the Universal Virus Database of the Intenational Committee on the Taxonomy of Viruses for the use of this image.